Blar i forfatter "Seternes, Ole Morten"

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    • Crosstalk between p38 MAPK and GR Signaling 

      Zeyen Øyås, Lisa; Seternes, Ole Morten; Mikkola, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-19)
      The p38 MAPK is a signaling pathway important for cells to respond to environmental and intracellular stress. Upon activation, the p38 kinase phosphorylates downstream effectors, which control the inflammatory response and coordinate fundamental cellular processes such as proliferation, apoptosis, and differentiation. Dysregulation of this signaling pathway has been linked to inflammatory diseases ...

    • Differences in PAR-2 activating potential by king crab (Paralithodes camtschaticus), salmon (Salmo salar), and bovine (Bos taurus) trypsin. 

      Larsen, Anett Kristin; Kristiansen, Kurt; Sylte, Ingebrigt; Seternes, Ole Morten; Bang, Berit (Journal article; Tidsskriftartikkel; Peer reviewed, 2013-07-20)
      Background: Salmon trypsin is shown to increase secretion of the pro-inflammatory cytokine interleukin (IL)-8 from human airway epithelial cells through activation of PAR-2. Secretion of IL-8 induced by king crab trypsin is observed in a different concentration range compared to salmon trypsin, and seems to be only partially related to PAR-2 activation. This report aim to identify differences in ...

    • Digital Marine Bioprospecting: Mining New Neurotoxin Drug Candidates from the Transcriptomes of Cold-Water Sea Anemones 

      Urbarova, Ilona; Karlsen, Bård Ove; Okkenhaug, Siri; Seternes, Ole Morten; Johansen, Steinar; Emblem, Åse (Journal article; Tidsskriftartikkel; Peer reviewed, 2012-10-18)
      Marine bioprospecting is the search for new marine bioactive compounds and large-scale screening in extracts represents the traditional approach. Here, we report an alternative complementary protocol, called digital marine bioprospecting, based on deep sequencing of transcriptomes. We sequenced the transcriptomes from the adult polyp stage of two cold-water sea anemones, Bolocera tuediae and Hormathia ...

    • Direct small RNA signatures in extracellular vesicles from breast cancer cell lines 

      Fiskaa, Tonje; Knutsen, Erik; Nikolaisen, Malene; Jørgensen, Tor Erik; Johansen, Steinar Daae; Perander, Maria; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-08-31)
      Breast cancer is a heterogeneous disease, and different subtypes of breast cancer show distinct cellular morphology, gene expression, metabolism, motility, proliferation, and metastatic potential. Understanding the molecular features responsible for this heterogeneity is important for correct diagnosis and better treatment strategies. Extracellular vesicles (EVs) and their associated molecules ...

    • Dual-specificity MAP kinase phosphatases in health and disease 

      Seternes, Ole Morten; Kidger, Andrew M; Keyse, Stephen M (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-08)
      It is well established that a family of dual-specificity MAP kinase phosphatases (MKPs) play key roles in the regulated dephosphorylation and inactivation of MAP kinase isoforms in mammalian cells and tissues. MKPs provide a mechanism of spatiotemporal feedback control of these key signalling pathways, but can also mediate crosstalk between distinct MAP kinase cascades and facilitate interactions ...

    • Early response evaluation by single cell signaling profiling in acute myeloid leukemia 

      Tislevoll, Benedicte Sjo; Hellesøy, Monica; Fagerholt, Oda Helen Eck; Gullaksen, Stein-Erik; Srivastava, Aashish; Birkeland, Even; Kleftogiannis, Dimitrios; Ayuda Duran, Pilar; Piechaczyk, Laure Isabelle; Tadele, Dagim Shiferaw; Skavland, Jørn; Panagiotis, Baliakas; Hovland, Randi; Andresen, Vibeke; Seternes, Ole Morten; Tvedt, Tor Henrik Anderson; Aghaeepour, Nima; Gavasso, Sonia; Porkka, Kimmo; Jonassen, Inge; Fløisand, Yngvar; Enserink, Jorrit; Blaser, Nello; Gjertsen, Bjørn Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-07)
      Aberrant pro-survival signaling is a hallmark of cancer cells, but the response to chemotherapy is poorly understood. In this study, we investigate the initial signaling response to standard induction chemotherapy in a cohort of 32 acute myeloid leukemia (AML) patients, using 36-dimensional mass cytometry. Through supervised and unsupervised machine learning approaches, we find that reduction of ...

    • ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells 

      Bian, Ka; Muppani, Naveen Reddy; Elkhadragy, Lobna; Wang, Wei; Zhang, Cheng; Chen, Tenghui; Jung, Sungyun; Seternes, Ole Morten; Long, Weiwen (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-19)
      Posttranslational modifications (PTMs), such as phosphorylation and ubiquitination, play critical regulatory roles in the assembly of DNA damage response proteins on the DNA damage site and their activities in DNA damage repair. Tyrosyl DNA phosphodiesterase 2 (TDP2) repairs Topoisomerase 2 (Top2)-linked DNA damage, thereby protecting cancer cells against Top2 inhibitors-induced growth inhibition ...

    • Identification of a core EMT signature that separates basal-like breast cancers into partial- and post-EMT subtypes 

      Knutsen, Erik; Sajib, Saikat Das; Fiskaa, Tonje; Lorens, James Bradley; Gudjonsson, Thorarinn; Mælandsmo, Gunhild Mari; Johansen, Steinar Daae; Seternes, Ole Morten; Perander, Maria (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-04)
      Epithelial-mesenchymal transition (EMT) is a cellular plasticity program critical for embryonic development and tissue regeneration, and aberrant EMT is associated with disease including cancer. The high degree of plasticity in the mammary epithelium is reflected in extensive heterogeneity among breast cancers. Here, we have analyzed RNA-sequencing data from three different mammary epithelial cell ...

    • Infection and microbial molecular motifs modulate transcription of the interferon-inducible gene ifit5 in a teleost fish 

      Bela-Ong, Dennis; Greiner-Tollersrud, Linn; van der Wal, Yorick Andreas; Jensen, Ingvill; Seternes, Ole Morten; Jørgensen, Jorunn (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-21)
      Interferon-induced proteins with tetratricopeptide repeats (IFITs) are involved in antiviral defense. Members of this protein family contain distinctive multiple structural motifs comprising tetratricopeptides that are tandemly arrayed or dispersed along the polypeptide. IFIT-encoding genes are upregulated by type I interferons (IFNs) and other stimuli. IFIT proteins inhibit virus replication by ...

    • Mixed exposure to bacterial lipopolysaccharide and seafood proteases augments inflammatory signalling in an airway epithelial cell model (A549) 

      Bhagwat, Sampada Satchidanand; Larsen, Anett Kristin; Seternes, Ole Morten; Bang, Berit (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-07-06)
      Seafood industry workers exhibit increased prevalence of respiratory symptoms due to exposure to bioaerosols containing a mixture of bioactive agents. In this study, a human pulmonary epithelial cell model (A549) was exposed to mixtures of bacterial lipopolysaccharide (LPS) and protease-activated receptor-2 (PAR-2) agonists H-Ser-Leu-Ile-Gly-Lys-Val-NH2 (SLIGKV-NH2), purified salmon (Salmo salar) ...

    • Novel Scaffolds for Dual Specificity Tyrosine-Phosphorylation-Regulated Kinase (DYRK1A) Inhibitors 

      Czarna, Anna Lucja; Jinhua, Wang; Zelencova, Diana; Liu, Yao; Deng, Xianming; Choi, Hwan Geun; Zhang, Tinghu; Zhou, Wenjun; Chang, Jae Won; Kildalsen, Hanne; Seternes, Ole Morten; Gray, Nathanael S.; Engh, Richard Alan; Rothweiler, Ulli (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-10)
      DYRK1A is one of five members of the dual-specificity tyrosine (Y) phosphorylation-regulated kinase (DYRK) family. The DYRK1A gene is located in the Down syndrome critical region and regulates cellular processes related to proliferation and differentiation of neuronal progenitor cells during early development. This has focused research on its role in neuronal degenerative diseases, including ...

    • On the Therapeutic Potential of ERK4 in Triple-Negative Breast Cancer 

      Boudghene-Stambouli, Fadia; Soulez, Mathilde; Ronkina, Natalia; Dörrie, Anneke; Kotlyarov, Alexey; Seternes, Ole Morten; Gaestel, Matthias; Meloche, Sylvain (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-21)
      ERK3 and ERK4 define a distinct and understudied subfamily of mitogen-activated protein kinases (MAPKs). Little is known about the physiological roles of these atypical MAPKs and their association with human diseases. Interestingly, accumulating evidence points towards a role for ERK3 and ERK4 signaling in the initiation and progression of various types of cancer. Notably, a recent study reported ...

    • Performance Comparison of Digital microRNA Profiling Technologies Applied on Human Breast Cancer Cell Lines 

      Knutsen, Erik; Fiskaa, Tonje; Ursvik, Anita; Jørgensen, Tor Erik; Perander, maria; Lund, Eiliv; Seternes, Ole Morten; Johansen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      MicroRNA profiling represents an important first-step in deducting individual RNA-based regulatory function in a cell, tissue, or at a specific developmental stage. Currently there are several different platforms to choose from in order to make the initial miRNA profiles. In this study we investigate recently developed digital microRNA high-throughput technologies. Four different platforms were ...

    • Phosphoproteomic analysis identifies supervillin as an ERK3 substrate regulating cytokinesis and cell ploidy 

      Javary, Joaquim; Goupil, Eugénie; Soulez, Mathilde; Kanshin, Evgeny; Bouchard, Antoine; Seternes, Ole Morten; Thibault, Pierre; Labbé, Jean-Claude; Meloche, Sylvain (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-28)
      Extracellular signal-regulated kinase 3 (ERK3) is a poorly characterized member of the mitogen-activated protein (MAP) kinase family. Functional analysis of the ERK3 signaling pathway has been hampered by a lack of knowledge about the substrates and downstream effectors of the kinase. Here, we used large-scale quantitative phosphoproteomics and targeted gene silencing to identify direct ERK3 substrates ...

    • Phosphorylation of steroid receptor coactivator-3 (SRC-3) at serine 857 is regulated by the p38 MAPK-MK2 axis and affects NF-κB-mediated transcription 

      Shrestha, Anup; Bruckmüller, Henrike; Kildalsen, Hanne; Kaur, Gurjit; Gaestel, Matthias; Ljones Wetting, Hilde; Mikkola, Ingvild; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-09)
      Steroid receptor coactivator-3 (SRC-3) regulates the activity of both nuclear hormone receptors and a number of key transcription factors. It is implicated in the regulation of cell proliferation, inflammation and in the progression of several common cancers including breast, colorectal and lung tumors. Phosphorylation is an important regulatory event controlling the activities of SRC-3. Serine 857 ...

    • Protein kinase A opposes the phosphorylation-dependent recruitment of glycogen synthase kinase 3β to A-kinase Anchoring Protein 220 

      Whiting, Jennifer L.; Nygren, Patrick J.; Tunquist, Brian J.; Langeberg, Lorene K.; Seternes, Ole Morten; Scott, John D. (Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-18)
      The proximity of an enzyme to its substrate can influence rate and magnitude of catalysis. A-kinase anchoring protein 220 (AKAP220) is a multivalent anchoring protein that can sequester a variety of signal transduction enzymes. These include protein kinase A (PKA) and glycogen synthase kinase 3 (GSK3). Using a combination of molecular and cellular approaches we show that GSK3 phosphorylation of ...

    • Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2 

      Perander, Maria; Al-Mahdi, Rania; Jensen, Thomas Clemens; Nunn, Jennifer Ann Lillebo; Kildalsen, Hanne; Johansen, Bjarne Herold; Gabrielsen, Mads; Keyse, Stephen M; Seternes, Ole Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-03-02)
      The atypical MAP kinases ERK3 and ERK4 are activated by phosphorylation of a serine residue lying within the activation loop signature sequence S-E-G. However, the regulation of ERK3 and ERK4 phosphorylation and activity is poorly understood. Here we report that the inducible nuclear dual-specificity MAP kinase phosphatase (MKP) DUSP2, a known regulator of the ERK and p38 MAPKs, is unique amongst ...